Abbreviation: CD152/CTLA-4
Target Synonym: CTLA4;ALPS5;CD;CD152;CELIAC3;CTLA-4;GRD4;GSE;IDDM12
Conjugation: Unconjugated
UNIProt ID: P16410
Background: This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.
Concentration: 1mg/mL
Immunogen: Recombinant fusion protein of human CD152/CTLA-4
Dilution: WB 1:500-1:2000,IHC 1:50-1:200
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