Products from BPS Bioscience require a minimum order value above 400€
Encompassing Amino Acids: 27-343
Application: Useful for avidin pull down assays.
Background: CD155 (also known as PVR cell adhesion molecule) is a transmembrane glycoprotein receptor of the immunoglobulin superfamily of proteins. It is highly expressed in dendritic cells, fibroblasts, endothelial cells, and multiple tumor cells including ovarian carcinoma, non-small cell lung, glioblastoma, and colorectal carcinoma. It has a high affinity for a T cell regulatory transmembrane surface protein called TIGIT (T cell immunoglobulin and ITIM domains) and plays a key role in tumor cell invasion and migration. Interaction between CD155 and TIGIT causes immunosuppressive effects on CD4+ and CD8+ T cells, which hinders T cell proliferation and function. CD155 also interacts with the regulatory receptors CD226 (expressed on natural killer (NK) cells, monocytes and CD4+ T cells) and CD96. While CD155-CD226 engagement activates NK cell cytotoxicity and T cell response, CD155-CD96 interaction inhibits NK cell function. Due to these opposing regulatory effects, blockade of CD155-TIGIT and CD155- CD226 interactions are attractive therapeutic strategies in cancer immunotherapy and autoimmune diseases, respectively.
Description: Recombinant human CD155, encompassing amino acids 27-343. This construct contains a C-terminal human IgG1 Fc domain followed by an Avi-Tag™. This protein was affinity purified.
Format: Aqueous buffer solution.
Formulation: 8 mM phosphate, pH 7.4, 110 mM NaCl, 2.2 mM KCl, and 20% glycerol
Genbank: NM_006505
Host Cell Line: HEK293
Purity: ≥90%
Storage Stability: At least 6 months at -80°C.
Tags: C-terminal Fc, C-terminal Avi-Tag™
Warnings: Avoid freeze/thaw cycles
Biosafety Level: Not applicable (BSL-1)
English
Deutsch
