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Encompassing Amino Acids: 29-265
Application: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Assay Conditions: Assay was generally performed according to CD200:CD200R1 [Biotinylated] Inhibitor Screening Chemiluminescence Assay Kit (#82285) with various amounts of CD200R1, Avi-His-Tag, Biotin Labeled Recombinant protein.
Background: CD200R1 (cluster of differentiation 200 receptor 1), also known as OX-2R, is a transmembrane glycoprotein. It is found in cells of the myeloid and lymphoid lineage, such as CD4+ cells. It acts as an immune inhibitory receptor, but contrary to other proteins with the same function, it does exhibit an ITIM (tyrosine-based inhibitory motif) domain. When bound to CD200 it contributes to the formation of an immunosuppressive TEM (tumor microenvironment), via a Dok1 (docking protein 1), Dok2 and RasGAP dependent mechanism, leading to T cell responses inhibition, NK cell cytotoxicity decrease, potentiation of Treg cell expansion and decrease of other immune responses to cancer cells. In addition to cancer, CD200 is linked to auto-immune disorders, inflammation, infection, graft survival and cancer. Samalizumab, an anti-CD200 monoclonal antibody, has resulted in positive outcomes when used in patients suffering from CLL (chronic lymphocytic leukemia) and MM (multiple myeloma). Inhibition of the interaction between CD200 and CD200R1 may thus be beneficial as a new therapy approach in CD200-related diseases.
Description: Recombinant human CD200R1 (cluster of differentiation 200 receptor 1), encompassing the extracellular amino acids 29-265. This construct contains a C-terminal Avi-Tag™ followed by a His-Tag (6xHis). This protein was affinity purified.
Format: Aqueous buffer solution.
Formulation: 8 mM phosphate pH 7.4, 110 mM NaCl, 2.2 mM KCl, and 20% glycerol
Genbank: NM_138806.4
Host Cell Line: HEK293
Purity: ≥90%
Storage Stability: At least 6 months at -80°C.
Uniprot: Q8TD46
Warnings: Avoid multiple freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
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