CD34 Monoclonal FITC Antibody (Clone ICO-115)

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Formulation: 500 µg of ammonium sulfate-purified, fluorescein labeled monoclonal antibody

Clone Designation: ICO-115

Shelf life (days): 180

Notes: CD34 is a transmembrane phosphoglycoprotein and sialomucin protein that is commonly used as a marker for hematopoietic progenitor cells.{59706,59704} It is composed of an N-terminal signaling peptide, a sialylated and O-glycosylated extracellular mucin domain, a cysteine-containing globular domain, a juxtamembrane stalk region, and an intracellular C-terminal tail.{59705} CD34 is expressed primarily in hematopoietic progenitor cells but is also expressed in mesenchymal stromal, muscle satellite, interstitial, epithelial and vascular endothelial progenitor, and adipose mesenchymal stem/stromal cells.{59706,59705} It has both pro- and anti-adhesion activities, providing an anchor for L-selectin-mediated attachment of lymphocytes in vascular endothelial cells and blocking adhesion of bone marrow-derived mast cells in vitro.{59706,59707} CD34 has commonly been used as a marker for the selection and enrichment of hematopoietic stem cells for bone marrow transplants.{59706} Cayman’s CD34 Monoclonal FITC Antibody (Clone ICO-115) can be used for flow cytometry (FC) and immunofluorescence (IF) applications.

• SKU: CAY10208-500
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 10208-500
• Package Unit: 1 ea (500 µg)
• Quantity Unit: STK
• Clonality: Monoclonal
• Application: Immunofluorescence, Flow Cytometry
• Isotype: IgG1
• Host: Mouse
• Conjugate: Conjugated, FITC