Products from BPS Bioscience require a minimum order value above 400€
Applications: Great for studying enzyme kinetics and screening small molecular inhibitors for drug discovery and HTS applications.
Background: CD38, a differentiation antigen of B lymphocytes, is a type II integral membrane protein that functions as an ADP-ribosyl cyclase and nicotinamide adenine dinucleotide (NAD) glycohydrolase. The major enzymatic activity of CD38 is the hydrolysis of NAD. Through its production of cyclic ADP-ribose, CD38 modulates calcium-mediated signal transduction in various cells, including pancreatic ß cells. CD38 is a prognostic biomarker for acute B lymphoblastic leukemia.
Description: The Dog CD38 Inhibitor Screening Assay Kit (Hydrolase Activity) is designed to measure the glycohydrolase activity of canine CD38 for screening and profiling applications.
Storage Stability: Up to 6 months from date of receipt, when stored as recommended
Supplied As: The CD38 assay kit comes in a convenient 96-well format, with recombinant dog CD38 enzyme, its substrate N6-etheno-NAD (ε-NAD), and CD38 assay buffer. In addition, the kit includes the CD38 inhibitor apigenin for use as a control inhibitor.
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
References: Koguma, T., et al. Biochim. Biophys. Acta -- Mol. Cell. Res. 1994. 1223(1): 160-162
Malavasi, F., et al. Physiol. Rev. 2008. 88(3): 841-886
English
Deutsch
