Products from BPS Bioscience require a minimum order value above 400€
Applications: Great for studying enzyme kinetics and screening small molecular inhibitors for drug discovery and HTS applications.
Background: CD38, a differentiation antigen of B lymphocytes, is a type II integral membrane protein. It is also known as ADP-ribosyl cyclase and nicotinamide adenine dinucleotide (NAD) glycohydrolase. Through its production of cyclic ADP-ribose, CD38 modulates calcium-mediated signal transduction in various cells, including pancreatic β cells. The major enzymatic activity of CD38 is the hydrolysis of NAD. CD38 is a prognostic biomarker for acute B lymphoblastic leukemia.
Description: The Mouse CD38 Inhibitor Screening Assay Kit (Hydrolase Activity) is designed to measure the glycohydrolase activity of mouse CD38 for screening and profiling applications. The CD38 assay kit comes in a convenient 96-well format, with purified recombinant murine CD38 enzyme, its substrate N6-etheno-NAD (ε-NAD), and CD38 assay buffer for 96 enzyme reactions. In addition, the kit includes the CD38 inhibitor apigenin for use as a control inhibitor.
Storage Stability: Stable at least 6 months from date of receipt, when stored as directed. Kit components require different storage conditions. Be sure to store each component at the proper temperature upon arrival
Warnings: Avoid multiple freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
References: Wei, W., et al., World J. Biol. Chem. 2014 5(1):58-67.Lund, F., et al., Mol. Med. 2006 12(11-12):328-333.
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