Products from BPS Bioscience require a minimum order value above 400€
Applications: Great for studying enzyme kinetics and screening small molecular inhibitors for drug discovery and HTS applications.
Background: CD38, a differentiation antigen of B lymphocytes, is a type II integral membrane protein that functions as an ADP-ribosyl cyclase and nicotinamide adenine dinucleotide (NAD) glycohydrolase. The major enzymatic activity of CD38 is the hydrolysis of NAD. Through its production of cyclic ADP-ribose, CD38 modulates calcium-mediated signal transduction in various cells, including pancreatic β cells. CD38 is a prognostic biomarker for acute B lymphoblastic leukemia.
Description: The Rat CD38 Inhibitor Screening Assay Kit (Hydrolase Activity) is designed to measure the glycohydrolase activity of rat CD38 for screening and profiling applications.
Storage Stability: Up to 6 months from date of receipt, when stored as recommended.
Warnings: Avoid multiple freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
References: Koguma, T., et al. Biochim. Biophys. Acta Mol. Cell. Res. 1994. 1223(1): 160-162
Malavasi, F., et al. Physiol. Rev. 2008. 88(3): 841-886
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