Clone Name: RA3-6B2
Light Chain: Kappa
Application Note: FACS: Use 0.25μg for 10^6 cells. IF: Use at a dilution of 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Form: Liquid
Buffer (with preservative): PBS, 0.1% BSA, 0.1% Sodium azide.
Concentration: 0.5 mg/ml (Please refer to the vial label for the specific concentration.)
Background: CD45R is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. CD45R contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains. It is specifically expressed in hematopoietic cells and has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. CD45R also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Four alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported.
Antigen Species: Mouse
Immunogen: Abelson murine leukemia virus-induced pre-B tumor cells.
Purification: Protein G purified
Conjugation: FITC
Full Name: protein tyrosine phosphatase, receptor type, C
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