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Encompassing Amino Acids: 2-346(end)
Background: CDK20 is a member of the cyclin-dependent kinase (CDK) family, which plays crucial roles in regulating cell cycle progression and cell division. The exact function of CDK20 is not well established. In humans, CDK20 activates CDK2 (cyclin-dependent kinase 2). CDK20 also seems to bind KEAP1 (Kelch-like ECHD-associated protein 1), which in turn will target NRF2 (nuclear factor erythroid-2-related factor) for degradation. The development of radio chemoresistance during cancer treatment by radiotherapy is one of the main causes of cancer recurrence. Absence of CDK20 in a lung cancer model resulted in decreased cell proliferation and increased sensitivity to radio chemotherapy. CDK20 is thus a promising therapeutic target in cancer therapy.
Description: Recombinant mouse CDK20 (cyclin dependent kinase 20), full length encompassing amino acids 2-346 (end). This construct contains an N-terminal GST-tag followed by thrombin cleavage site. The recombinant protein was affinity purified.
Formulation: 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 20% glycerol, and 3 mM DTT
Genbank: NM_053180
Purity: ≥90%
Storage Stability: At least 6 months at -80°C.
Supplied As: Aqueous buffer solution.
Tags: N-terminal GST-tag
Uniprot: Q9JHU3
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
References: 1. Liu, Y. et.al, J. Biol. Chem. 2004 ; 279: 4507-4514.
2. Yang Y. et.al, EMBO Rep. 2013;14(8):741-7.
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