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Encompassing Amino Acids: 2-90
Applications: Useful for protein binding assays, screening inhibitors, and selectivity profiling.
Background: Chromodomain proteins are components of heterochromatin-like complexes and can act as gene repressors. CDY1 contains a chromodomain and a histone acetyltransferase catalytic domain. CDY1 has histone acetyltransferase activity, with a preference for histone H4. This protein is localized to the nucleus of late spermatids where histone hyperacetylation takes place. Histone hyperacetylation is thought to facilitate the transition in which protamines replace histones as the major DNA-packaging protein.
Description: Human chromodomain protein Y-linked 1 (CDY1), also known as CDY and testis-specific chromodomain protein Y 1, GenBank Accession No. NM_170723, a.a. 2-90, with N-terminal His-tag, MW=11.7 kDa, expressed in an E. coli cell expression system.
Format: Aqueous buffer solution
Formulation: 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 300 mM imidazole, 0.04% Tween20, 20% glycerol.
Genbank: NM_170723
Storage Stability: At least 6 months at -80°C.
Tags: N-terminal His-tag
Uniprot: Q9Y6F8
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
References: 1. Fischle, W., et al., J Biol Chem. 2008
Jul 11;283(28):19626-35.
2. Kleiman, S.E., et al., Fertil Steril. 2011
Jun;95(7):2297-302.
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