Formulation: A solid
Formal Name: (6R,7R)-7-[[2-[2-(aminomethyl)phenyl]acetyl]amino]-3-[[[1-(carboxymethyl)-1H-tetrazol-5-yl]thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Purity: ≥95%
Formula Markup: C20H21N7O6S2
Formula Weight: 519,6
Shelf life (days): 1460
CAS Number: 60925-61-3
Notes: Ceforanide is a cephalosporin antibiotic.{68467} It is active against the Gram-positive bacteria S. pyogenes, S. pneumoniae, V. streptococci, S. aureus, and S. epidermidis (MICs = 0.5, 0.2-0.5, 2, 8, and 6.2 µg/ml, respectively), as well as the Gram-negative bacteria E. coli, P. mirabilis, and K. pneumoniae (MIC50s = 1.6, 0.8, and 1.6 µg/ml, respectively). In vivo, ceforanide (30 mg/kg) reduces the number of colony forming units (CFUs) in vegetations and increases survival in a rabbit model of S. aureus-induced endocarditis.{68468} Formulations containing ceforanide have been used in the treatment of bacterial infections.
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