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Applications: Useful for the kinase assay kits and Western blotting.
Background: CK1γ1 or casein kinase 1, gamma 1 is belonging to the most abundant serine/threonine kinase in eukaryotic cell extracts which is mainly involved in growth and morphogenesis of eukaryotic cells. Casein kinase 1, gamma 1 possesses a C-terminal most terminal sequence motif (MTM), which it shares with CSNK1G2 and CSNK1G3 which is associated with heterologous carboxy-terminal sequences (1). Casein kinase 1-gamma couples Wnt receptor activation to the cytoplasmic signal transduction apparatus (2).
Description: Recombinant human CK1γ1 (21-end) also known as CK1G1, CSNK1G1, and CKI-γ 1. Genbank Accession NM_022048 with an N--terminal GST-tag, expressed in Sf9 cells via a baculovirus expression system. MW = 70-76kDa.
Format: Aqueous buffer solution
Formulation: 50 mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Genbank: NM_00220948
Purity: ≥95%
Storage Stability: At least 6 months at -80°C. Avoid freeze/thaw cycles.
Tags: GST-Tag
Uniprot: Q9HCP0
Biosafety Level: Not applicable (BSL-1)
References: 1. Kusuda, J., et al., Cytogenet. Cell Genet. 2000;90:298-302.
2. Davidson, G., et al., Nature. 2005;438:867-872.
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