Clone Name: ARC5062-02
Application Note: IHC-P: 1:500-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Calculated MW: 28
Form: Liquid
Buffer (with preservative): PBS pH 7.3, 0.05% BSA, 50% glycerol, 0.05% proclin300.
Concentration: Batch dependent (Please refer to the vial label for the specific concentration.)
Background: This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is upregulated in patients with ulcerative colitis and highly overexpressed in infiltrating ductal adenocarcinomas. PKC/MAPK/AP-1 (protein kinase C/mitogen-activated protein kinase/activator protein-1) dependent pathway regulates the expression of this gene in gastric cells. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jun 2010]
Uniprot ID: P56856
Antigen Species: Human
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CLDN18.2 (P56856-2).
Purification: Purified by affinity chromatography
Conjugation: Unconjugated
Full Name: claudin 18
English
Deutsch
