Abbreviation: Complement factor D
Target Synonym: CFD;ADIPSIN;ADN;DF;PFD
Conjugation: Unconjugated
UNIProt ID: P00746
Background: This gene encodes a member of the S1, or chymotrypsin, family of serine peptidases. This protease catalyzes the cleavage of factor B, the rate-limiting step of the alternative pathway of complement activation. This protein also functions as an adipokine, a cell signaling protein secreted by adipocytes, which regulates insulin secretion in mice. Mutations in this gene underlie complement factor D deficiency, which is associated with recurrent bacterial meningitis infections in human patients. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature protease.
Concentration: 1mg/mL
Immunogen: Recombinant fusion protein of human Complement factor D
Dilution: WB 1:500-1:2000
English
Deutsch
