Product Description: Cys-McMMAF is the released payload of AlMcMMAF, an anti-5T4 humanized A1 antibody conjugated to the microtubule disrupting MMAF (HY-15579) via a maleimidocaproyl linker. Cys-McMMAF has antitumor efficacy in two tumor mouse models (H1975 and MDA-MB-361-DYT2 models)[1].
Applications: Cancer-programmed cell death
Formula: C52H83N7O13S
References: [1]Leal M, et al. Preclinical Development of an anti-5T4 Antibody-Drug Conjugate: Pharmacokinetics in Mice, Rats, and NHP and Tumor/Tissue Distribution in Mice. Bioconjug Chem. 2015 Nov 18;26(11):2223-32.
CAS Number: 1160590-05-5
Molecular Weight: 1046.32
Compound Purity: 99.91
Research Area: Cancer
Solubility: DMSO : 200 mg/mL (ultrasonic)
Target: Microtubule/Tubulin