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Clone Name: MSVA-544M
Light Chain: Kappa
Product Description: This antibody was validated on 76 different Normal Tissues by IHC-P.
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Application Note: IHC-P: 1:75-1:150. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Calculated MW: 114
Positive Control: Tonsil: A moderate to strong desmoglein 1 immunostaining should be seen in a fraction of squamous epithelial cells.
Negative Control: Desmoglein 1 immunostaining should be absent in all non-squamous epithelial cell types.
Form: Liquid
Buffer (with preservative): 10mM PBS, 0.05% BSA (Please contact us for BSA and azide free format), 0.05% sodium azide.
Concentration: 0.2 mg/ml (Please refer to the vial label for the specific concentration.)
Background: This gene encodes a member of the desmoglein protein subfamily. Desmogleins, along with desmocollins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmoglein family members on chromosome 18. The encoded protein has been identified as a target of auto-antibodies in the autoimmune skin blistering disease pemphigus foliaceus. Disruption of this gene has also been associated with the skin diseases palmoplantar keratoderma and erythroderma. [provided by RefSeq, Feb 2015]
Uniprot ID: Q02413
Antigen Species: Human
Immunogen: Bovine desmoglein (desmosomal glyco protein I) from nasal epidermis.
Purification: Protein A/G purified
Conjugation: Unconjugated
Full Name: desmoglein 1
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