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Background: DLL1 is involved in cell-to-cell communication and in embryonic development, neurogenesis, and tissue homeostasis. It is a member of the Delta-Serrate-Lag2 (DSL) family of ligands that activate the Notch signaling pathway. DLL1 binds to the Notch receptors on neighboring cells, triggering signals that regulate cell fate determination, proliferation, and differentiation. Dysregulation of DLL1 has been implicated in several diseases.
Description: Recombinant human DLL1 (delta like canonical Notch ligand 1), encompassing amino acids 18-540. This construct contains a C-terminal Avi-Tag™ followed by a His-tag (6xHis). The recombinant protein was affinity purified.
Format: Aqueous buffer solution.
Formulation: 8 mM phosphate, pH 7.4, 110 mM NaCl, 2.2 mM KCl, and 20% glycerol
Genbank: NM_005618.4
Host Cell Line: HEK293
Purity: ≥90%
Storage Stability: At least 6 months at -80°C.
Tags: C-terminal Avi-Tag™
Uniprot: O00548
Warnings: Avoid freeze/thaw cycles
Biosafety Level: Not applicable (BSL-1)
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