(E/Z)-IT-603, CAS 292168-90-2

Formulation: A solid

Formal Name: 5-[(5-bromo-2-hydroxy-3-methoxyphenyl)methylene]-2-thioxo-4-imidazolidinone

Purity: ≥98%

Formula Markup: C11H9BrN2O3S

Formula Weight: 329,2

Shelf life (days): 1460

CAS Number: 292168-90-2

Notes: (E/Z)-IT-603 is a c-Rel inhibitor (IC50 = 3 µM).{72125} It inhibits c-Rel DNA binding to the IL2 promoter in an EMSA. (E/Z)-IT-603 reduces the proliferation of OCI-Ly3 diffuse large B cell lymphoma cells (IC50 = 18 µM). It reduces Huh7 epithelial carcinoma spheroid growth when used at a concentration of 20 µM in combination with the anthracycline antitumor antibiotic doxorubicin (Item No. 15007).{72126} Preincubation of (E/Z)-IT-603 (20 µM) with murine T cells co-administered with A20 murine lymphoma cells to lethally irradiated mice as a model of T cell-depleted bone marrow transplantation reduces allo-stimulation without affecting anticancer T cell responses and increases survival.{72125} In vivo, (E/Z)-IT-603 (24 mg/kg every other day), when used in combination with doxorubicin, reduces hepatic tumor burden, increases CD8+ T cell and F4/80+ macrophage tumor infiltrates, and increases tumoral mRNA encoding chemokine (C-X-C motif) ligand 9 (Cxcl9) in a Hep-53.4 murine hepatocellular carcinoma model.{72126}

• SKU: CAY37792-10
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 37792-10
• Green Labware: No
• Package Unit: 10 mg
• Quantity Unit: STK