Product Type: Inhibitor
CAS No.: N/A
MolecularFormula: C30H50N2O2
Molecular Weight: 470,7
Source: Synthetic
Purity: >98% (TLC); NMR (Conforms)
Solubility: May be dissolved in DMSO (30 mg/ml); or ethanol (20 mg/ml, warm)
Appearance: Beige powder
Scientific Background: A natural product found in coffee which synergizes with caffeine in protecting the brain in models of alpha-synucleinopathy (1). It inhibits the PP2A methylesterase maintaining PP2A in a highly active state leading to hypophosphorylated alpha-synuclein. In mouse models it preserved neuronal integrity and function, diminished neuroinflammation and improved behavioral performance. It prevents ABeta-induced impairments in mouse models of Alzheimer’s disease (2,3).
References: 1. Yan R., et al. (2018) Proc. Natl. Acad. Sci. USA . 115:E120532. Asam K., et al. (2017) PLoS One. 12:e01894133. Basurto-Islas G., et al. (2014) Neurobiol. Aging. 35:2701
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
English
Deutsch
