Clone Name: 50000000000
Light Chain: Kappa
Application Note: WB: 1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Calculated MW: 36
Form: Liquid
Buffer (with preservative): PBS, 10% Glycerol, 0.02% Sodium azide.
Concentration: 1 mg/ml (Please refer to the vial label for the specific concentration.)
Background: The translation initiation factor EIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, EIF2, and GTP. EIF2 is composed of 3 nonidentical subunits, the 36-kD EIF2-alpha subunit (EIF2S1), the 38-kD EIF2-beta subunit (EIF2S2; MIM 603908), and the 52-kD EIF2-gamma subunit (EIF2S3; MIM 300161). The rate of formation of the ternary complex is modulated by the phosphorylation state of EIF2-alpha (Ernst et al., 1987 [PubMed 2948954]).[supplied by OMIM, Feb 2010]
Uniprot ID: P05198
Antigen Species: Human
Immunogen: The clone 5E10 is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human EIF2S3 protein.
Purification: Protein G Purified
Conjugation: Unconjugated
Full Name: eukaryotic translation initiation factor 2 subunit alpha
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