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Clone Name: RW128
Light Chain: Kappa
Application Note: WB: 1:250 - 1:500. ICC/IF: 1:10 - 1:2000. FACS: 1 μg/ml. IP: 1:10 - 1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Calculated MW: 264
Form: Liquid
Buffer (with preservative): PBS, 0.1% Sodium azide.
Concentration: 1 mg/ml (Please refer to the vial label for the specific concentration.)
Background: This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer. [provided by RefSeq]
Uniprot ID: Q09472
Antigen Species: Human
Immunogen: Fusion protein containing residues 1572-2371 of human KAT3B/p300. [UniProt# Q0947]
Purification: Protein A purified
Conjugation: Unconjugated
Full Name: E1A binding protein p300
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