Abbreviation: ERO1LB
Target Synonym: ERO1B;ERO1LB;Ero1beta
Conjugation: Unconjugated
UNIProt ID: Q86YB8
Background: Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Other protein disulfide isomerase family members can also be reoxidized, but at lower rates compared to P4HB, including PDIA2 (50% of P4HB reoxidation rate, as well as PDIA3, PDIA4, PDIA6 and NXNDC12 (<10%. Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS in the cell. May be involved in oxidative proinsulin folding in pancreatic cells, hence may play a role in glucose homeostasis.
Concentration: 1mg/mL
Immunogen: Recombinant fusion protein of human ERO1LB
Dilution: WB 1:500-1:2000
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