Formulation: A solid
Formal Name: 2-[3-[4-(4-fluorophenyl)-1-piperazinyl]propyl]-2H-naphth[1,8-cd]isothiazole, 1,1-dioxide
Purity: ≥98%
Formula Markup: C23H24FN3O2S
Formula Weight: 425,5
Shelf life (days): 1460
CAS Number: 127625-29-0
Notes: Fananserin is an antagonist of the serotonin (5-HT) receptor subtype 5-HT2 (IC50 = 0.12 nM for the rat receptor).{72541} It is selective for 5-HT2 over 5-HT1A, 5-HT3, the α1-adrenergic receptor (α1-AR), dopamine D2 receptor (IC50s = 75, 6,600, 4.3, and 390 nM, respectively, for the rat receptors), and histamine H1 receptor (IC50 = 50 nM for the guinea pig receptor). Fananserin is also an antagonist of the dopamine D4 receptor (Ki = 2.93 nM for the human receptor).{72542} It inhibits the head-twitch response (HTR) induced by mescaline in mice (ED50 = 0.16 mg/kg). Fananserin (2 or 4 mg/kg) increases time in deep non-rapid eye movement (NREM) sleep and decreases time in light NREM sleep in rats.{72543} It increases the time spent in the open arms of the elevated plus maze in mice when administered at doses of 0.25, 1, or 4 mg/kg.{72544}
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