Clone Name: CRA1
Application Note: ICC/IF: 2-10 μg/ml. IHC-P: 2-10 μg/ml. IHC-Fr: 2-10 μg/ml. FACS: 2-10 μg /ml. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Calculated MW: 30
Specificity/Sensitivity: The CRA1 (AER37) monoclonal antibody reacts with the Fc epsilon R1 alpha subunit on a region that does not overlap the region of the IgE binding site, thus it does not compete withIgE for the receptor binding. Since the CRA2 (AER24) monoclonal antibody reacts with the IgE binding site on Fc epsilon R1 alpha, it competes with IgE for the receptor binding. Combining the two antibodies, one can quantitatively measure the amounts of the IgE-bound Fc epsilon R1 alpha.
Form: Liquid
Buffer (with preservative): Filter-sterilized PBS (pH7.4), 50% Glycerol, no preservative.
Concentration: 1 mg/ml (Please refer to the vial label for the specific concentration.)
Background: The immunoglobulin epsilon receptor (IgE receptor) is the initiator of the allergic response. When two or more high-affinity IgE receptors are brought together by allergen-bound IgE molecules, mediators such as histamine that are responsible for allergy symptoms are released. This receptor is comprised of an alpha subunit, a beta subunit, and two gamma subunits. The protein encoded by this gene represents the alpha subunit. [provided by RefSeq, Aug 2011]
Uniprot ID: P12319
Antigen Species: Human
Immunogen: Recombinant extracellular protein of human Fc epsilonR1alpha; (corresponding to amino acids Met-26-197, where signal peptide is 1-25)
Epitope: 26-110 amino acids
Purification: Purified IgG
Conjugation: FITC
Full Name: Fc fragment of IgE receptor Ia
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