FEN1-IN-4, CAS 1995893-58-7

Formulation: A solid

Formal Name: 1-(cyclopropylmethyl)-3-hydroxy-2,4(1H,3H)-quinazolinedione

Purity: ≥98%

Formula Markup: C12H12N2O3

Formula Weight: 232,2

Shelf life (days): 1460

CAS Number: 1995893-58-7

Notes: FEN1-IN-4 is an inhibitor of flap endonuclease 1 (FEN1; IC50 = 30 nM for FEN1-336Δ).{69542} It also inhibits exonuclease 1 in a concentration-dependent manner. FEN1-IN-4 (10 µM) inhibits ATP-induced mitochondrial DNA (mtDNA) fragmentation and levels of cytosolic mtDNA in LPS-primed primary mouse bone marrow-derived macrophages (BMDMs).{69543} It also inhibits ATP-induced phosphorylation of STING in LPS-primed wild-type and Nlrp3-/- primary mouse BMDMs. FEN1-IN-4 (40 mg/kg) decreases peritoneal levels of IL-1β and neutrophil and monocyte infiltration in a mouse model of alum-induced peritonitis.

• SKU: CAY37790-10
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 37790-10
• Green Labware: No
• Package Unit: 10 mg
• Quantity Unit: STK