Formulation: A solid
Formal Name: (2S,3aS,4S,5R,7R,8S,8aS,9R)-octahydro-2,8a-dihydroxy-4,8,9-trimethyl-1-oxo-5-(2,3,5,8-tetrahydro-1,3-dioxo-2-phenyl-1H-[1,2,4]triazolo[1,2-a]pyridazin-6-yl)-1H-3a,8-propanoazulen-7-yl ester, 2-chloro-acetic acid
Purity: ≥90%
Formula Markup: C30H36ClN3O7
Formula Weight: 586,1
Shelf life (days): 1460
CAS Number: 2505218-38-0
Notes: Ferroptocide is an inhibitor of thioredoxin (Trx) and a derivative of pleuromutilin (Item No. 19452).{67521} It inhibits Trx activity in ES-2 ovarian cancer cells when used at a concentration of 20 µM and is cytotoxic to ES-2 cells (IC50 = 1.6 µM). Ferroptocide (5 µM) induces ferroptosis in ES-2 cells, an effect that can be blocked by the iron chelator deferoxamine (DFO; Item No. 14595), antioxidant Trolox (Item No. 10011659), or ferroptosis inhibitor ferrostatin-1 (Item No. 17729). It decreases tumor volume in a 4T1 murine mammary carcinoma model using immunocompetent but not immunodeficient mice when administered at 50 mg/kg twice per week.
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