Formulation: 500 µl of peptide affinity-purified polyclonal antibody
Immunogen: Peptide from the C-terminal region of human fibrinogen (α chain)
Shelf life (days): 1095
Notes: Fibrinogen is a hexameric glycoprotein that has roles in coagulation and hemostasis.{53514,53515} It is comprised of two sets of Aα, Bβ, and γ polypeptide chains encoded by FGA, FGB, and FGG, respectively, in humans.{53514} Fibrinogen is synthesized in hepatocytes and secreted into the plasma. Following thrombin-mediated cleavage of N-terminal fibrinopeptides from the Aα and Bβ chains, yielding the α and β chains, respectively, fibrinogen assembles into fibrin protofibrils and then mature fibers, which provide structure and viscoelasticity to blood clots.{53515,53516,53518} Mutations in FGA, FGB, or FGG have been found in patients with afibrinogenemia or hypofibrinogenemia.{53514} Elevated plasma fibrinogen levels are associated with an increased risk of cardiovascular disease.{53517} Immune complexes containing citrullinated fibrinogen have been found in patients with anti-citrullinated protein antibody-positive rheumatoid arthritis.{21643} Cayman's Fibrinogen (α chain) Polyclonal Antibody can be used for Western blot applications. The antibody recognizes the α chain of fibrinogen at 70 kDa from human samples.
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