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Encompassing Amino Acids: full length
Applications: Useful for testing rapamycin inhibition of mTOR.
Background: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruites SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity.
Description: Human FKBP12 (FK506 binding protein 1A, transcript variant 12A), GenBank Accession No. NM_054014, full length with N-terminal His-tag, MW= 13.1 kDa, expressed in an E. coli expression system. 5References: 1. Knappe,T.A. et al., J. Mol. Biol. 368 (5), 1458-1468 (2007). 2. Wear,M.A. et al., Protein Expr. Purif. 51 (1), 80-95 (2007).
Format: Aqueous buffer solution
Formulation: 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 50% glycerol.
Genbank: NM_054014
Storage Stability: Store at -80°C. Stable for >6 months when stored as directed.
Tags: N-terminal His-tag
Uniprot: P62942
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
References: 1. Knappe,T.A. et al., J. Mol. Biol. 368 (5),1458-1468 (2007).
2. Wear,M.A. et al., Protein Expr. Purif. 51 (1),80-95 (2007).Application Reference:Structure of glutaraldehyde cross-linked ryanodine receptor (2013)
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