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Applications: Great for studying enzyme kinetics and HTS applications.
Background: MALT1 (Mucosa-associated lymphoid tissue lymphoma translocation protein 1) is a cysteine protease that structurally resembles caspases. MALT1 is a member of the CARMA1-BCL10-MALT1 (CBM) complex that mediates NF-κB activation downstream of the B cell receptor, T cell receptor and ITAM-coupled natural killer cell receptors. MALT1 cleavage activity is essential to T cell and B cell activation and is linked to the pathogenesis of activated B cell-like diffuse large B cell lymphoma (ABC-DLBCL), a chemoresistant form of DLBCL.
Description: The Fluorogenic MALT1 Assay Kit is designed to measure MALT1 activity for screening and profiling applications, in a homogeneous assay with no time-consuming washing steps.
Storage Stability: One year from date of receipt when stored as directed.
Supplied As: The MALT1 assay kit comes in a convenient 96-well format, with purified MALT1 enzyme, fluorogenic substrate, and MALT1 assay buffer for 100 enzyme reactions.
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)