Fluoxetine HCl, CAS 56296-78-7

Serotonin reuptake inhibitor

Product Type: Inhibitor

CAS No.: 56296-78-7

MolecularFormula: C17H18F3NO • HCl

Molecular Weight: 345,8

Source: Synthetic

Purity: ≥98% (HPLC); NMR (Conforms)

Solubility: May be dissolved in DMSO (35 mg/ml); or water (4 mg/ml)

Appearance: White powder

PubChem CID: 62857

Scientific Background: A selective serotonin reuptake inhibitor (SSRI) with high selectivity for the serotonin transporter (Kd=0.81 nM) over the norepinephrine (Kd=240 nM) and dopamine (Kd=3.6 M) transporters(1). A clinically useful antidepressive agent (2). Has shown some potential in autism spectrum disorders (3). Attenuates neuroinflammation in early brain injury after subarachnoid hemorrhage (4). Orally active and active in vivo. Increases proliferation of neuronal precursors derived from human embryonic stem cells, inducing differentiation and strongly enhancing neuronal characteristics (5).

References: 1. M Tatsumi et al. Eur. J. Pharmacol. 1997 340:2492. P Benfield et al. Drugs 1986 32:4813. A Benvenuto et al. Brain Dev. 2013 35:1194. FY Liu et al. J. Neuroinflammation 2018 15:3475. EA Chang et al. Int. J. Dev. Biol. 2010 54:707

Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• SKU: STRSIH-631-1G
• Manufacturer: Stressmarq Biosciences
• Manufacturer SKU: SIH-631-1G
• Package Unit: 1 g
• Quantity Unit: STK