Product Description: Fmoc-8-amino-3,6-dioxaoctanoic acid (Fmoc-NH-PEG2-CH2COOH) is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-8-amino-3,6-dioxaoctanoic acid is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Applications: Cancer-programmed cell death
Formula: C21H23NO6
References: [1]Nakamura A, et al. Chemogenetic Control of Protein Anchoring to Endomembranes in Living Cells with Lipid-Tethered Small Molecules. Biochemistry. 2020 Jan 21;59(2):205-211.
CAS Number: 166108-71-0
Molecular Weight: 385.41
Compound Purity: 99.98
Research Area: Cancer
Solubility: DMSO : 25 mg/mL (ultrasonic;warming;heat to 60°C)