Target: FNIP1.
Conjugate: HRP.
Product Type: Polyclonal.
Immunogen: Synthetic peptide from the mid-protein of Human FNIP1.
Swiss-Prot: Q8TF40.
Purification: Peptide Affinity Purified.
Storage Buffer: PBS, 50% glycerol, 0.09% sodium azide.
Concentration: 1 mg/ml.
Specificity: Detects ~130 kDa.
Cellular Localization: Cytoplasm .
Tissue Specificity: Strong expression is found in the heart, liver placenta, muscle, nasal mucosa, salivary gland and uvula and moderate expression in kidney and lung. Higher levels detected in clear cell renal cell carcinoma (RCC) and chromophobe RCC than in normal kidney tissue.
Scientific Background: Folliculin-interacting protein 1 (FNIP1) is a co-chaperone of HSP90 (1). It Inhibits the ATPase activity of HSP90AA1 leading to reduction in its chaperone activity. It may be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways and may regulate the phosphorylation of RPS6KB1 (2). FNIP1 is strongly expressed in the heart, liver placenta, muscle, nasal mucosa, salivary gland, and uvula. Elevated levels of FNIP1 have been detected in renal cell carcinoma (RCC) (3).
References: 1. Woodford, M. R. et al. (2016) Nature Com. 12037.2. Baba, M. et al. (2006) Proc Natl Acad Sci U.S.A. 103(42):15552-7.3. www.uniprot.org/uniprot/Q8TF54.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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