Product Description: Formamide (Standard) is the analytical standard of Formamide. This product is intended for research and analytical applications. Formamide is an effective DNA denaturant that significantly reduces the stability of DNA in buffer solutions. It induces apoptosis by promoting the formation of cyclic nucleotides and the phosphorylation and dephosphorylation processes of nucleotides, making it useful in cancer research. Formamide can also be used as a decalcifying agent for rat cardiac cells. Additionally, formamide is widely used as a solvent or chemical raw material for ion compounds, resins, and plasticizers.[1][2][3][4][5][6][7]
Formula: CH3NO
References: [1]Kamineni VK, et al. Layer-by-layer nanoassembly of polyelectrolytes using formamide as the working medium. Langmuir. 2007;23(14):7423-7./[2]Blake RD, et al. Thermodynamic effects of formamide on DNA stability. Nucleic Acids Res. 1996 Jun 1;24(11):2095-103./[3]Costanzo G, et al. Formamide as the main building block in the origin of nucleic acids. BMC Evol Biol. 2007 Aug 16;7 Suppl 2(Suppl 2):S1./[4]Brette F, et al. Validation of formamide as a detubulation agent in isolated rat cardiac cells. Am J Physiol Heart Circ Physiol. 2002 Oct;283(4):H1720-8./[5]Frankfurt OS, Krishan A. Identification of apoptotic cells by formamide-induced dna denaturation in condensed chromatin. J Histochem Cytochem. 2001 Mar;49(3):369-78./[6]Messier PE.Messier PE. Effects of formamide on neuroepithelial cells and on interkinetic nuclear migration in the chick embryo. J Embryol Exp Morphol. 1976 Feb;35(1):197-212./[7]National Toxicology Program. Toxicology and carcinogenesis studies of formamide (Cas No. 75-12-7) in F344/N rats and B6C3F1 mice (gavage studies). Natl Toxicol Program Tech Rep Ser. 2008 Jul;(541):1-192.
CAS Number: 75-12-7
Molecular Weight: 45.04
Research Area: Cancer
Target: Apoptosis;Biochemical Assay Reagents
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