FT113, CAS 1630808-89-7

Formulation: A solid

Formal Name: [4-[4-(6-fluoro-2-benzoxazolyl)benzoyl]-1-piperazinyl](1-hydroxycyclopropyl)-methanone

Purity: ≥98%

Formula Markup: C22H20FN3O4

Formula Weight: 409,4

Shelf life (days): 1460

CAS Number: 1630808-89-7

Notes: FT113 is an inhibitor of fatty acid synthase (FASN; IC50 = 213 nM).{67541} It inhibits the proliferation of PC3 human prostate cancer and MV4-11 human acute myeloid leukemia cells (IC50s = 47 and 26 nM, respectively) and inhibits FASN activity in a 14C-acetate incorporation assay using BT474 human breast cancer cells (IC50 = 90 nM). FT113 (25 and 50 mg/kg) reduces tumor growth and increases intratumoral levels of the FASN substrate malonyl-CoA in an MV4-11 mouse xenograft model. It also inhibits infection of HEK293T cells expressing human angiotensin-converting enzyme 2 (HEK293T-hACE2 cells) with an infectious-clone-derived mNeonGreen severe acute respiratory syndrome coronavirus 2 reporter virus (SARS-CoV-2-mNG) with an EC50 value of 17 nM.{66011}

• SKU: CAY37545-10
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 37545-10
• Green Labware: No
• Package Unit: 10 mg
• Quantity Unit: STK