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Clone Name: MSVA-602M
Light Chain: Kappa
Product Description: This antibody was validated on 76 different Normal Tissues by IHC-P.
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Application Note: IHC-P: 1:100-1:200. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Calculated MW: 65
Positive Control: Pancreas: A strong GAD2 staining should be seen in pancreatic islet cells.
Negative Control: Colon: GAD2 immunostaining should be absent in all cell types
Form: Liquid
Buffer (with preservative): 10mM PBS, 0.05% BSA (Please contact us for BSA and azide free format), 0.05% sodium azide.
Concentration: 0.2 mg/ml (Please refer to the vial label for the specific concentration.)
Background: This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Oct 2008]
Uniprot ID: Q05329
Antigen Species: Human
Immunogen: Recombinant human GAD2 (GAD65) protein fragment (around aa 6-99)
Purification: Protein A/G purified
Conjugation: Unconjugated
Full Name: glutamate decarboxylase 2
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