Abbreviation: GATA3
Target Synonym: GATA 3,GATA binding factor 3,GATA binding protein 3,GATA-binding factor 3,Gata3,GATA3,HDR,HDRS,MGC2346,MGC5199,MGC5445,Trans acting T cell specific transcription factor GATA 3,Trans-acting T-cell-specific transcription factor GATA-3
Conjugation: Unconjugated
Clone NO.: YN02076m
Background: GATA binding protein 3 (GATA3) is a member of the GATA family of transcription factors (including six members: GATA-1 to GATA-6). It plays an important role in promoting and guiding cell proliferation, development and differentiation in many tissues and cell types. GATA-3 is widely expressed in the epithelial cells of mammary duct glandular cavity and urinary tract epithelium, but not in myoepithelial cells. The expression of GATA-3 is closely associated with the expression of estrogen receptor-α in breast cancer,and there is evidence that GATA-3 can be used to predict the response to hormone therapy in breast cancer patients, and has also been shown to be a new marker for bladder cancer.
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