Clone Name: 1G12
Light Chain: Kappa
Application Note: IHC-P: 1:100-1:200. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Calculated MW: 66
Positive Control: Prostate intraepithelial neoplasia (PIN)
Form: Liquid
Buffer (with preservative): Tissue culture supernatant diluted in Tris-HCl buffer, 0.2% BSA, 0.09% Sodium azide.
Concentration:
Background: Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The protein encoded by this gene can bind to and inhibit the dipeptidyl peptidase activity of CD26, and it can induce apoptosis in certain cell types. Deletion mutations in this gene are associated with Simpson-Golabi-Behmel syndrome, also known as Simpson dysmorphia syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]
Uniprot ID: P51654
Antigen Species: Human
Immunogen: A fragment containing the last 70 amino acids of human core glypican-3 protein
Purification: unpurified
Conjugation: Unconjugated
Full Name: glypican 3
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