Background: Disruption of the disabled-1 gene (Dab1) results in aberrant migration of neurons during development and disorganization of laminar structures throughout the brain. Dab1 is thought to function as an adaptor molecule in signal transduction processes. It contains a protein-protein interaction (PI) similar to the phosphotyrosine binding domain of the Shc oncoprotein, it is phosphorylated by the Src protein tyrosine kinase, and it binds to SH2 binding domains in a phosphotyrosine dependent manner. Disabled Ð1 acts downstream of reelin in a signalling pathway.
Positive Control: 293 cells transfected with Dab-1 HA tag.
Purification Method: Ammonium Sulfate Precipitation.
Source: Goats were immunized with a recombinant protein corresponding to amino acids 1-179 of mouse disabled coupled to a GST fusion protein.
Formulation: Provided as 0.2ml sterile filtered solution in phosphate buffered saline with 0.08% sodium azide.
References: 1. Howell B.W. et.al (1997). EMBO Journal 1,121-132
2. Homayouni,R. et.al (1999) J. Neuroscience 19(17), 7505-7515.
UniProt: P97318 (Mouse).
Caution: This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.
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