GPR109A/HM74A/HCAR2 Polyclonal Antibody, Rabbit

Abbreviation: GPR109A/HM74A/HCAR2

Target Synonym: HCAR2;GPR109A;HCA2;HM74a;HM74b;NIACR1;PUMAG;Puma-g

Conjugation: Unconjugated

UNIProt ID: Q8TDS4

Background: Acts as a high affinity receptor for both nicotinic acid (also known as niacin and (D-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. The rank order of potency for the displacement of nicotinic acid binding is 5-methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamide.

Concentration: 1mg/mL

Immunogen: A synthetic peptide of human GPR109A/HM74A/HCAR2

Dilution: WB 1:500-1:2000,IHC 1:50-1:200

• SKU: ELSE-AB-93136-120
• Manufacturer: Elabscience Biotechnology
• Manufacturer SKU: ELA-E-AB-93136-120
• Green Labware: No
• Package Unit: 120 µl
• Quantity Unit: STK
• Reactivity: Human, Mouse (Murine), Rat (Rattus)
• Clonality: Polyclonal
• Application: Western Blotting, Immunohistochemistry
• Isotype: IgG
• Host: Rabbit