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Encompassing Amino Acids: 1-345(end)
Application: Useful for for animal immunization, ELISA, and PK assay.
Assay Conditions: Immobilized Human GPRC5D VLP at 5 µg/mL (100 µl/Well) on the plate.
Background: G protein-coupled receptor class C group 5 member D (GPRC5D) is an orphan receptor of little-known function belonging to the large family of G protein-coupled receptors. The protein is highly expressed in malignant plasma cells such multiple myeloma and is now considered a therapeutic target for antibody-based treatment of multiple myeloma. For example, CAR T cells and GPCR5DxCD3 bispecific antibodies are under development.
Biological Activity: Dose response curve for Anti-GPRC5D Antibody, hFc Tag with the EC50 of <11.8 ng/mL determined by ELISA.
Description: Human GPRC5D (G-protein coupled receptor family C group 5 member D) protein (VLP), full length encompassing amino acids 1-345(end). This construct is tag-free.
Endotoxin Level: <1 EU/µg (determined by LAL method)
Format: Aqueous buffer solution.
Formulation: Supplied as a 0.22 µm filtered solution of PBS, pH 7.4. Notice: If you need it for immunization, do not use any adjuvant.
Purity: ≥95% (determined by HPLC)
Storage Stability: Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage.
Uniprot: Q9NZD1-1
Warnings: Avoid freeze/thaw cycles. If you need it for immunization, do not use any adjuvant.
Biosafety Level: BSL-1
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