Application Note: IHC-P: 1:200-1:400. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Calculated MW: 21
Form: Liquid
Buffer (with preservative): Aqueous buffered solution, 1% BSA, 50% glycerol, 0.09% Sodium azide.
Concentration: 1 mg/ml (Please refer to the vial label for the specific concentration.)
Background: This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to relay the sonic hedgehog (SHH) signal from the polarizing region to the apical ectodermal ridge during limb bud outgrowth. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
Uniprot ID: O60565
Antigen Species: Human
Immunogen: KLH conjugated synthetic peptide derived from human gremlin 1 (101-184).
Purification: Protein A purified
Conjugation: Unconjugated
Full Name: gremlin 1, DAN family BMP antagonist
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