Application Note: WB: 1:300-1:1000. IHC-P: 1:200-1:400. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Calculated MW: 72
Form: Liquid
Buffer (with preservative): Aqueous buffered solution, 1% BSA, 50% Glycerol, 0.09% Sodium azide.
Concentration: 1 mg/ml (Please refer to the vial label for the specific concentration.)
Background: This gene encodes a member of the type I cytokine receptor family, which is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. In humans and rabbits, but not rodents, growth hormone binding protein (GHBP) is generated by proteolytic cleavage of the extracellular ligand-binding domain from the mature growth hormone receptor protein. Multiple alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jun 2011]
Uniprot ID: P10912
Antigen Species: Human
Immunogen: KLH conjugated synthetic peptide derived from human GHR (290-340/638).
Purification: Protein A purified
Conjugation: Unconjugated
Full Name: growth hormone receptor
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