GSK25, CAS 874119-56-9

Formulation: A solid

Formal Name: 4-(4-chloro-2-fluorophenyl)-2-(2-chloro-4-pyridinyl)-N-(6-fluoro-1H-indazol-5-yl)-1,4-dihydro-6-methyl-5-pyrimidinecarboxamide

Purity: ≥98%

Formula Markup: C24H16Cl2F2N6O

Formula Weight: 513,3

Shelf life (days): 1460

CAS Number: 874119-56-9

Notes: GSK25 is an inhibitor of Rho-associated kinase 1 (ROCK1; IC50 = 7 nM for the human kinase).{72121} It is selective for ROCK1 over p90 ribosomal S6 kinase 1 (RSK1) and p70 ribosomal S6 kinase (p70S6K; IC50s = 398 and 1,000 nM, respectively) and is greater than 100-fold selective over a panel of 31 additional kinases. GSK25 induces relaxation in precontracted isolated rat aortic rings (EC50 = 256 nM). In vivo, GSK25 (30 mg/kg) decreases mean arterial blood pressure in spontaneously hypertensive rats.

• SKU: CAY39163-1
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 39163-1
• Green Labware: No
• Package Unit: 1 mg
• Quantity Unit: STK