Products from BPS Bioscience require a minimum order value above 400€
Encompassing Amino Acids: 1-1152 (end)
Applications: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Assay Conditions: Assay was done according to HDAC6 Fluorogenic Assay Kit (BPS Bioscience #50076) with various amounts of HDAC6.
Background: Histone Deacetylases (HDACs) are involved in histone deacetylation, which regulates transcription. HDAC6 is involved in multiple cellular processes, such as leptin sensitivity, cell motility, mitosis and stress granule formation. Overexpression of HDAC6 is linked to tumor formation, and mutations have been associated with Alzheimer's disease. The use of HADC6 inhibitors presents high therapeutic potential for the treatment of neurodegenerative diseases and cancer.
Description: Recombinant rat full length HDAC6 (Histone Deacetylase 6) encompassing amino acids 1-1152(end). The construct contains a N- terminal GST-Tag. This protein was affinity purified
Format: Aqueous buffer solution.
Formulation: 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 0.04% Tween-20 and 20% glycerol
Genbank: XM_003752010.4
Host Cell Line: Sf9 cells
Purity: ≥80%
Storage Stability: At least 6 months at -80°C.
Tags: N-Terminal GST Tag
Uniprot: A0A0G2QC41
Warnings: Avoid freeze/thaw cycles
Biosafety Level: Not applicable (BSL-1)
English
Deutsch
