Products from BPS Bioscience require a minimum order value above 400€Encompassing Amino Acids: 2-103(end)
Applications: Useful as a substrate for histone methyltransferase and acetyltransferase assays. Ideal for screening small molecular inhibitors of histone modifying enzymes for drug discovery and HTS applications.
Description: Human Histone 4 (HIST2H4A) (GenBank Accession No. NM_003548), a.a. 2-103(end) with N-terminal His-tag, MW = 12.1 kDa, expressed in an E. coli expression system.
Format: Aqueous buffer solution
Formulation: 8 mM PBS pH 7.4, 110 mM NaCl, 2.2 mM KCl, 3 mM DTT, and 20% glycerol
Genbank: NM_003548
Host Cell Line: E. coli
Storage Stability: At least 6 months at -80°C.
Tags: N-terminal His-tag
Uniprot: P62805
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
References: 1. Kornberg, R.D. (1977) Annu. Rev. Biochem., 46, 931-954.
2. van Holde, K.E. (1989) Chromatin, 1-497.Application Reference(s):
1.
Differential mode of antimicrobial actions of arginine-rich and lysine-rich histones against Gram-positive Staphylococcus aureus (2013)
2. Extracellular histones are essential effectors of C5aR- and C5L2-mediated tissue damage and inflammation in acute lung injury (2013)
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