Abbreviation: HLA-DPB1
Target Synonym: DPB1;HLA-DP;HLA-DP1B;HLA-DPB;HLA-DPB1;major histocompatibility complex;class II;DP beta 1
Conjugation: Unconjugated
UNIProt ID: P04440
Background: HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules. [provided by RefSeq, Jul 2008]
Concentration: 1mg/mL
Immunogen: A synthetic peptide of human HLA-DPB1
Dilution: WB 1:500-1:2000,IHC 1:50-1:100,IF 1:50-1:200
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