Application Note: WB: 1:1000-1:3000. ICC/IF: 1:200-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Calculated MW: 22
Form: Liquid
Buffer (with preservative): Filter-sterilized 0.12M Sodium Phosphate buffer (pH7.4), 50% Glycerol, no preservative.
Concentration: 0.37 mg/ml (Please refer to the vial label for the specific concentration.)
Background: This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family. The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The encoded product is involved in the formation of functional kinetochore through interaction with essential kinetochore proteins. The gene has a pseudogene located on chromosome 3. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
Uniprot ID: P45973
Antigen Species: Human
Immunogen: The product is prepared by immunizing rabbit with the synthetic peptide CEDAENKEKETAKS corresponding to the amino acid sequence 179-191 of human HP1 alpha
Purification: Purified IgG
Conjugation: Unconjugated
Full Name: chromobox 5
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