Target: HSP47
Conjugate: Unconjugated
Product Type: Monoclonal
Clone Number: 1C4-1A6
Immunogen: Human HSP47, full length
Swiss-Prot: P50454.2
Purification: Protein G Purified
Storage Buffer: PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
Concentration: 1 mg/ml
Specificity: Detects 47kDa.
Cellular Localization: Endoplasmic Reticulum,Endoplasmic Reticulum Lumen
Scientific Background: HSP47 is a chaperone protein, member of the superfamily of serine proteinase inhibitors. Also known as SERPINH1, a serine proteinase inhibitor. It is a stress protein that resides in the endoplasmic reticulum, has an active role on the intracellular process of folding, assembly and secretion of pro-collagens. Recent studies have shown the association of on an increased expression of HSP47 around fibrotic lesions (1).The identification of a novel biomarker on cell therapies aimed to reduce the progression of fibrotic diseases, could be used potentially as a universal marker, since HSP47 binds a single substrate (2). Type I collagen is fundamental during the healing process after a myocardial infarction. It is critical in the position of collagen-produced cells and the assembly of collagen fibrils (3).
References: 1. Razzaque MS., Taquchi T., (1999) Histol Histopathol. 14 (4): 1999-212.2. Taguchi T., et al. (2011) Acta Histochem Cytochem. 44(2):35-41. 3. Nong Z., et al. (2011) Am J Pathol. 197(5): 2189-96.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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