Species: Human
Product Description: GM-CSF, a colony stimulating factor also known as CSF2, mediates the proliferation, differentiation, and functions of hematopoietic precursor cells. This bioactive recombinant human GM-CSF is a 14.6 kDa globular protein formed by a 128 a.a. polypeptide with two intramolecular disulfide bonds and two potential N-linked glycosylation sites.
Application Note: The ED₅₀ was determined by a cell proliferation assay using TF-1 cells is ≤ 0.1 ng/ml, corresponding to a specific activity of ≥ 1 x 10⁷ units/mg.
Form: Lyophilized powder
Buffer (with preservative): Reconstitute with distilled water to 0.1 mg/ml. Lyophilized from 50mM PBS, 100mM NaCl, 5% Trehalose, no Preservative.
Concentration: (Please refer to the vial label for the specific concentration.)
Background: The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include those encoding interleukins 4, 5, and 13. [provided by RefSeq, Jul 2008]
Uniprot ID: P04141
Region Sequence: Human full-length GM-CSF protein (18-144 a.a. of NP_000749.2, signal peptide removed)
ExpressionSystem: E. Coli
Conjugation: Unconjugated
Full Name: colony stimulating factor 2
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