Species: Human
Form: Lyophilized powder
Buffer (with preservative): Reconstitute with distilled water to 0.9 mg/ml. Lyophilized from PBS, 2% Trehalose, 5% Mannitol, 0.01% Tween-80, no Preservative.
Concentration: (Please refer to the vial label for the specific concentration.)
Background: The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, Jul 2008]
Uniprot ID: P01584
Region Sequence: C-terminal His tagged full-length Human IL1B protein (1-269aa of NP_000567.1)
ExpressionSystem: HEK293 cells
Conjugation: Unconjugated
Full Name: interleukin 1 beta
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